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Symbol
Name
ID
Vegfa
vascular endothelial growth factor A
MGI:103178
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgG level
Decreased circulating antibody level
Paraproteinemia
Leukocytosis
Abnormal granulocyte morphology
Abnormal basophil morphology
Ph-positive acute lymphoblastic leukemia
Acute myeloid leukemia
Chronic myelogenous leukemia
Myeloproliferative disorder
Lymphadenopathy
Splenomegaly
Hepatosplenomegaly
Helicobacter pylori infection
Subacute progressive viral hepatitis
Acne
Skin rash
Autoimmunity
Disease(s) Associated with VEGFA
acute myeloid leukemia
chronic myeloid leukemia
hepatocellular carcinoma
multiple myeloma
pre-eclampsia
pseudoxanthoma elasticum

Mouse Phenotypes
immune system phenotype
enhanced leukocyte tethering or rolling
abnormal leukocyte adhesion
abnormal thymus morphology
thymus hypoplasia
athymia
ectopic thymus
increased mast cell number
decreased lymphocyte cell number
increased macrophage cell number
enlarged lymph nodes
abnormal lymphatic vessel morphology
enlarged lymphatic vessel
decreased inflammatory response
lung inflammation
Availability Mouse Genotype
Vegfatm1.1Nagy/Vegfatm1.1Nagy
Vegfatm1Pec/Vegfatm1Pec
Tg(KRT14-Vegfa)3Dtm/0
Vegfatm2Gne/Vegfatm2Gne
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
*
Vegfatm2Gne/Vegfatm2Gne
Tg(SFTPC-cre)#Mliu/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory